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![]() ![]() Thunderbolts will be directed by Jake Schreier. While plot details remain unknown, Louis-Dreyfus will star in Thunderbolts alongside Florence Pugh as Yelena Belova, David Harbour as Red Guardian, Harrison Ford as Thunderbolt Ross, Olga Kurylenko as Taskmaster, Wyatt Russell as US Agent, Hannah John-Kamen as Ghost and Sebastian Stan as Bucky Barnes. Feige also revealed at 2022's San Diego Comic-Con that the movie will mark the end of the MCU's Phase 5. Louis-Dreyfus confirmed that filming for Thunderbolts will begin in the summer of 2023. If you pick up the new issue of Rolling Stone, you'll get to see in Julia. They later rejected Baron, aiming to become heroes under the direction of Hawkeye. Ap/ 12:18 PM / CBS News Blame it on a drunken stupor. 2 #449 in January 1997, featuring a team of reformed supervillains founded by Baron Helmut Zemo. New York City, New York, USA Birth name Julia Elizabeth Scarlett Louis-Dreyfus Nickname Little Yum-Yum Height 5 3 (1.RELATED: RUMOR: Marvel Eyeing Ryan Gosling or Alexander Skarsgård for a Major VillainĬreated by Mark Bagley, the Thunderbolts debuted in The Incredible Hulk Vol. By Kevin Fraser JanuAfter making relatively brief appearances in The Falcon and the Winter Soldier, Black Widow, and Black Panther: Wakanda Forever, Julia Louis-Dreyfus is ready. People assume that we were told to put her in, but she was there from the beginning." After about a minute of comedically thanking everyone involved with her 'Veep' win, Julia Louis-Dreyfus paused. "And we had Val in there before she even appeared in any of the other movies, before Black Widow and Falcon and the Winter Soldier. When he sadly died in September 2016 at the age of 84 from complications around his congestive heart failure, she made sure to honor him in her Emmy acceptance speech. "Actually, in this version, was pared back in order to make space for dealing with T'Challa's death," said Wakanda Forever director Ryan Coogler. Initially, it was initially planned that Val would have a larger role in the Black Panther sequel, but this was scaled back following the death of Chadwick Boseman. She reprised the role in Black Panther: Wakanda Forever, where she mainly featured alongside Martin Freeman's Everett Ross, revealed to be her ex-husband. Louis-Dreyfus' first appearances in the MCU as Contessa Valentina Allegra de Fontaine, aka "Val," came in Disney+'s The Falcon and the Winter Soldier and a post-credits scene in 2021's Black Widow. ![]() And I didn’t want her to look too much like Cruella," she said. "I thought purple would make it a little more of this world today. Louis-Dreyfus discussed making the Contessa Valentina character her own, successfully tweaking the fictional CIA director's notable streak of white hair. RELATED: Thunderbolts' Julia Louis-Dreyfus Confirms When Filming StartsĪccording to the Veep star, she landed her first Marvel Cinematic Universe role just a few days after meeting with Marvel Studios President Kevin Feige and co-president Louis D'Esposito. ![]() ![]() ![]() You want to make sure to poke holes in the top of each with the tines of a fork to allow steam to escape as they bake. ![]() Place another square on top and use a fork to crimp the edges to prevent the filling from leaking out in the oven. Then add a 1-2 Tablespoons to a center of rectangle.įor the S’mores Poptarts, spread about 1 Tablespoon of fluff onto 1 rectangle and then top with Hershey squares. Add the filling.įor Frosted Strawberry poptarts place one tablespoon of jam in the center.įor the brown sugar cinnamon filling, s imply measure and place all the ingredients into a bowl and stir to combine. Using a pizza cutter, cut the dough into 8 even small rectangles. Trim dough so that all sides are even and straight. Remove one disk of dough from refrigerator and roll out on generously floured work surface to 13 by 9-inch rectangle about 1/8 inch thick. Then go ahead and wrap the crust in plastic wrap and refrigerate for at least 30 minutes to firm up the crust and make it cold! Shape the crust. If it’s dry and crumbly, then it needs more water. The crust if ready should hold together when you pinch some of it. Scrape down sides and bottom of bowl with rubber spatula. Add butter and process until homogenous dough just starts to collect in uneven clumps, about 10 seconds (dough will resemble cottage cheese curds with some very small pieces of butter remaining, but there should be no uncoated flour). Process flour and salt together in food processor until combined, about 2 one-second pulses. How to Make Homemade Pop Tarts Make the crust. Listed below are the ingredients you need to make all the fun variations! For The Pie Crust: I’ve included instructions for all three pop tart versions! Ingredients for Homemade Pop Tarts Isn’t’ being indecisive the best? Ok only in the kitchen is that probably true. Strawberry glazed? Brown Sugar Cinnamon? Or maybe it’s summer (or you’re longing for summer!) and want that S’mores without a campfire. And let me tell you, once you try the homemade version it will be hard to go back and tear open another silver package with your teeth ever again.Īs per usual, I couldn’t decide WHICH kind of pop tart to make. It seemed only natural that I would get around to making my own homemade version of the classic breakfast treat. Since my boxed pop tart days, I have found great satisfaction in making everything from scratch. Sometimes I even went to great lengths and actually used a toaster oven to heat them up. In my college and barely post college days, I would scarf these down for breakfast, snack, dinner …ok even dinner. I always went for the strawberry iced or the brown sugar cinnamon. I have to admit I have had more than my fair share of those silvery packaged (ok, I have to admit DRY) crumbly pastry tarts in my day. I’ll show you how to make homemade poptarts 3 ways! Frosted Strawberry Poptarts. A homemade version of the classic breakfast treat for when the kid in you cries out. Homemade Pop Tarts are 1000% better than store-bought. ![]() ![]() ![]() ![]() Cystinosis is one of the few rare diseases having a specific treatment. Cystinosis (ORPHA213) is a rare autosomal recessive lysosomal storage disorder in which the amino acid cystine accumulates in the lysosomes of cells. The currently used term “cystinosis” is a modification from the German term “Cystindiathese” or “hereditary cystine disease” which was initially used by Emil Abderhalden to describe the disease in 1903 and was modified in the English literature to “cystine disease” then “cystinosis”. Hence, cystinosis was also recognized in the literature as the Lignac-Fanconi syndrome. Guido Fanconi (1892–1979), the Swiss pediatrician, also substantially contributed to the understanding of cystinosis by explaining the urinary substance losing nature of the disease. This is why cystinosis was initially termed as the Abderhalden-Kaufmann-Lignac syndrome. The Dutch pathologist George Lignac (1891–1954) was the first to provide a clear systematic description of the disease in 1924, and the first to associate cystinosis with its major clinical manifestations such as rickets, renal disease and growth retardation. This patient died at the age of 21 months with massive cystine accumulation in multiple organs that were discovered at the postmortem examination. Abderhalden referred to a child initially encountered by Eduard Kaufmann, Basel, Switzerland (1860–1931). In the current review we will discuss the most important clinical features of the disease, advantages and disadvantages of the current diagnostic and therapeutic options and the main topics of future research in cystinosis.Ĭystinosis was first described in literature in 1903 by the Swiss biochemist Emil Abderhalden (1877–1950) as the familial cystine accumulation disease. Several lines of treatment are available for cystinosis including the cystine depleting agent cysteamine, renal replacement therapy, hormonal therapy and others however, no curative treatment is yet available. Leucocyte cystine assay is the cornerstone for both diagnosis and therapeutic monitoring of the disease. Other affected organs include eyes, thyroid, pancreas, gonads, muscles and CNS. The kidneys are initially affected during the first year of life through proximal tubular damage followed by progressive glomerular damage and end stage renal failure during mid-childhood if not treated. Defective cystinosin function leads to intra-lysosomal cystine accumulation in all body cells and organs. It is an autosomal recessive lysosomal storage disorder caused by mutations in the CTNS gene encoding for the carrier protein cystinosin, transporting cystine out of the lysosomal compartment. Cystinosis is the most common hereditary cause of renal Fanconi syndrome in children. ![]() ![]() ![]()
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